LGRK (Genomics and Radiobiology of Keratinopoiesis)
LGRK (Genomics and Radiobiology of Keratinopoiesis)
LGRK (Genomics and Radiobiology of Keratinopoiesis)
Description
The Genomics and Radiobiology of Keratinopoiesis Laboratory (LGRK) is part of the CEA’s François Jacob Institute of Biology.
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.
The first objective of the laboratory’s team is to characterize the properties of these cells in their normal state. The team seeks to identify the determinants of the stem-cell state and the self-renewal of stem keratinocytes, notably as concerns TGF-B1 regulatory pathways.
A second objective is to study these stem cells in pathological conditions. The team studies the role of stem keratinocytes in skin cancers (under ionizing radiation and UV light) and certain pathologies associated with rare dermatological disorders causing hypersensitivity to genotoxic agents, particularly Gorlin syndrome.
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.
The first objective of the laboratory’s team is to characterize the properties of these cells in their normal state. The team seeks to identify the determinants of the stem-cell state and the self-renewal of stem keratinocytes, notably as concerns TGF-B1 regulatory pathways.
A second objective is to study these stem cells in pathological conditions. The team studies the role of stem keratinocytes in skin cancers (under ionizing radiation and UV light) and certain pathologies associated with rare dermatological disorders causing hypersensitivity to genotoxic agents, particularly Gorlin syndrome.
Referent Contact
FORTUNEL Nicolas
Director
nicolas.fortunel@cea.fr
LGRK (Genomics and Radiobiology of Keratinopoiesis)
Address
CEA – Laboratoire de Génomique et Radiobiologie de la Kératinopïèse – DSV – Genopole Campus 2 – Bâtiment G2 – 2 rue Gaston-Crémieux – CP 5722
91057 Evry, Ile de France, France
91057 Evry, Ile de France, France
Contact
Description
The Genomics and Radiobiology of Keratinopoiesis Laboratory (LGRK) is part of the CEA’s François Jacob Institute of Biology.
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.
The first objective of the laboratory’s team is to characterize the properties of these cells in their normal state. The team seeks to identify the determinants of the stem-cell state and the self-renewal of stem keratinocytes, notably as concerns TGF-B1 regulatory pathways.
A second objective is to study these stem cells in pathological conditions. The team studies the role of stem keratinocytes in skin cancers (under ionizing radiation and UV light) and certain pathologies associated with rare dermatological disorders causing hypersensitivity to genotoxic agents, particularly Gorlin syndrome.
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.
The first objective of the laboratory’s team is to characterize the properties of these cells in their normal state. The team seeks to identify the determinants of the stem-cell state and the self-renewal of stem keratinocytes, notably as concerns TGF-B1 regulatory pathways.
A second objective is to study these stem cells in pathological conditions. The team studies the role of stem keratinocytes in skin cancers (under ionizing radiation and UV light) and certain pathologies associated with rare dermatological disorders causing hypersensitivity to genotoxic agents, particularly Gorlin syndrome.
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