Method of Enhancing Gene Therapy by Targeting cGAS-STING Pathway

Gene therapy

The present invention features method and composition that can be used to facilitate intracellular delivery of DNA to a subject. The provided methods and compositions employ a nanoparticle for intracellular DNA delivery and a cytosolic DNA-sensing inhibitor. The cytosolic DNA-sensing inhibitor is provided to decrease the subject’s immune response that can be stimulated by the DNA.

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