NAVIGATING FOR THE IDEAL BIOPROCESSING SOFTWARE SOLUTION

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The digital transformation of biomanufacturing processes – commonly referred to as “Bioprocessing 4.0” – imagines holistically interconnected and automated bioprocess equipment. In Bioprocessing 4.0 production concepts, biomanufacturing processes are run, monitored, controlled, and significantly improved in robustness through the implementation of dynamic feedback loops and mathematical modeling approaches (Bisschops & Cameron, 2022).

In this article, we present a modular master operation for bioprocesses using the software Lucullus®. The master operation can be applied to various cultivation settings within the same bioreactor system and can be easily transferred to other reactor systems and brands. This has the advantage that only a single process control recipe is required to effectively cover the entire spectrum of cultivations. In the realm of manufacturing, the processes are established, optimized, and tested and the previously modular process control recipes can be adjusted into rigid and fully automated configurations, primed for the validation process.

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