OSE Immunotherapeutics Announces Commercial and Revenue Sharing Agreement in the Field of CAR T-cell Therapies
This exclusive and worldwide agreement with Memorial Sloan Kettering Cancer Center (MSK) covers OSE Immunotherapeuticsâ patent rights and jointly owned OSE/MSK patent rights in the field of Chimeric Antigen Receptor (CAR) cell therapy for the treatment of Interleukin-7 Receptor (IL-7R) expressing cancers, in particular hematological tumors such as Acute Lymphoblastic Leukemia. As part of this agreement, MSK will lead the research, development, and commercialization efforts, and subsequently share potential future revenues with OSE Immunotherapeutics.
Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, said: âWe are very pleased to reinforce our collaboration with one of the worldâs most renowned US cancer hospitals in oncology and in particular in the field of CAR-T cell therapies. Based on their pioneering expertise in this area, we look forward to the clinical exploration of a potential breakthrough therapy option for IL-7R expressing cancer patientsâ.
âI am excited for the next steps in translation of IL-7R targeted CARs to clinical trials treating IL-7R expressing tumor bearing patients at MSK,’ said Prasad S. Adusumilli, MD, FACS, Deputy Chief and Attending, Thoracic Service, and Vice Chair for Translational Research, Department of Surgery, at MSK. Dr. Adusumilli holds the Min H. & Yu-Fan C. Kao Chair in Thoracic Cancer at MSK. His laboratory team investigated and developed therapeutic strategies using IL-7R CAR T cells.
This new agreement is based on the initial multi-year research collaboration between MSK and OSE Immunotherapeutics to explore the preclinical potential of a non-antagonist IL-7R monoclonal antibody directed against the alpha chain of IL-7R used either as a therapeutic antibody or for the design of innovative CAR-T cells for cancer indications expressing high level of IL-7R.